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August 16, 2004

Interleukin-6

This was interesting. If seems a protein, interleukin-6, fights obesity naturally.

A medical treatment to reduce obesity in humans without diet or exercise could be developed through research at RMIT.

Everyone always wants a short cut, don't they? If I wasn't thin I'd be one of them, too!

A team of medical scientists led by Mark Febbraio from RMIT's Skeletal Muscle Research Laboratory has isolated a protein, interleukin-6, which breaks down fat in adipose tissue in the human body and obese animals.

Tests on people in Melbourne and in Copenhagen, where a team of scientists is co-operating with the RMIT group, have shown the therapy to be effective against serious obesity and in helping patients suffering from Type 2 diabetes, in which obesity is also a factor. Interleukin-6 is naturally released by muscles in mammals during exercise but, the research has found, it can be injected into a human to reduce body fat by as much as 20 per cent.

So the body fat is tricked into thinking the muscles are actually doing something more than lifting potato chips, which is quite a clever little trick. I'd been thinking the eventual solution to obesity would be found in really heavy potato chips, but it seems there's a better way.

If the research leads to a viable, and approved, medical therapy it could be worth billions of dollars in the lucrative pharmaceutical market. But Associate Professor Febbraio is cautious. There seems no doubt that the treatment works and promises to be valuable in treating chronic obesity, but he does not believe it will lead to an over-the-counter weight reduction pill.

Taken orally, the protein is cleared by the liver before it can be effective and, he said, long-term use could result in the patient developing an immunity to its effects.

Well, I guess since the liver breaks it down you can't just run a cow around the ranch right before you shoot it, eat the meat, and have it make you thin. However many societies, including some North American Indian tribes, felt that if you eat a fast animal you become fast, and if you eat a slow pig you become one. Aside from fat content maybe they had noticed some small effect of some of these "exercise" proteins in the diet, but surely any such effect, if any exists, would be swamped by the fact that for the deer to be running the guy hunting the deer is running a hell of a lot too. Plus hauling it back and all that.

Still, I'm sure the method stands to make a fortune once they get any bugs worked out, such as the fact that injections are the only way to administer it, unless they can come up with a patch you can wear. Short of that we're all going to have the problem of telling the thin waifs with needle tracks from interleukin-6 from the thin waifs with needle tracks from heroin, while the cops will always here the plaintive cry "I'm just dieting, man…"

Monte Burns: Soooo.... I can pay Smithers to jog around the track for an hour, then give me a blood transfusion. He'll be doing all the work, and all be getting the benefits.... [rolls fingers]

August 16, 2004 in Science | Permalink

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Comments

Every time I see my doctor I ask about the "medicine that makes you exercise regularly" it has become a running gag. So far his best answers have been "Viagra" and "Find an attractive women who likes to walk and follow her."

Posted by: toad at Aug 17, 2004 6:25:00 PM

QUOTE(and BTW HTC to you get it ot appear in a blue box?!): Well, I guess since the liver breaks it down you can't just run a cow around the ranch right before you shoot it, eat the meat, and have it make you thin. UNQUOTE

CANDIDATE LC RESPONDS: Do not know about livers(yet) nor eating your very own cow(quoique...), but I DO know about running your very own cow around the ranch. In an attempt at teaching capitalism at 10 years old I have been awarded by my parents a cow, a Herford(all white in any case), and she was to be the start of my herd. I was not sure I gave a shit about the latter, but she was going to be halter fed in any case. The sound of my trusty Honda 70 trail bike terrified her, and she ran through multiple barbed wire fences on the fateful day I tried to cull her form the herd to start her halter training, about which I knew fookall, but heh, first things first. She became psychotic, and I may well have triggered that, hard to know. (Would have to try the same thing on hundreds of other cows to get solid statistics on that.) Anyhoo(IMAO rocks!..or maybe IMAO waltzes..it appears the Tshirt babe is getting coopted on this Grand Canyon thing), the lesson is that airing out your neighbors dog with your trusty Leopold scope mounted on your trusty 7mm Mag is cool as long as you dont tell the county police. The neighbors` dog, suspected of killing multiple calves on my parents ranch, got caught red-pawed in the sights of one heavily overpowered varmint rifle, by one ace deer hunter, chowing down on the first progeny of my herd. The mother may have been a bitch, and her daughter/son a lunch, but vital parts of the big bad wolf became a fine spray. Texas WolfGoblin Count, 356 thousand 872. Anyhoo(IMAO rocks), my relation with Charlotte the Herford, already challenged by her early psychosis, degraded inexorably, plummetted really, with the lost of her first child. If memory serves we did eat the father though, and that would be Oedipally correct I guess.

Cheers (sniff) Bryan

Posted by: Bryan Travis at Aug 17, 2004 10:01:28 PM

That's pretty funny, Bryan!

The bluebox is from using [blockquote] [/blockquote] where you use less-than greater-than signs instead of brackets.

Posted by: George Turner at Aug 18, 2004 1:44:44 AM

Posted by: Shchedrin at Mar 10, 2005 2:14:56 AM

Posted by: Bunin at Mar 29, 2005 8:39:44 PM

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