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August 18, 2004

New Protein Involved in Sleep and Anxiety

Ooo… This is good news. Researchers have found a protein that controls sleep and anxiety. I suffer from sleep problems, and a psycologist friend of mine says I have mild anxiety disorder. Although she wears Birkenstocks and sings the praises of patchouli oil (nearly fell out of my chair on that one, given how often I bash it), she's probably right.

Brain anti-anxiety switch found

Scientists have found a switch in the brain that appears to control anxiety and wakefulness.

In tests on rodents, the University of California team found a protein called NPS was active in areas of the brain governing arousal and anxiety.

This switch could be a target for drugs to treat sleep and anxiety disorders and attention deficit hyperactivity disorder, they hope.

The findings appear in the journal Neuron.

Scientists had recently discovered the brain protein neuropeptide S (NPS), but had not fully explored its actions

So we have a new brain chemical to investigate, one involved in sleep, anxiety, and attention disorders. What's interesting is the same chemical seems linked across them, and given the alleged enormous increase in childhood attention deficit disorders coinciding with kids staying up late chatting, watching late night TV, and playing on the computer, maybe the increase is more real than imagined.

August 18, 2004 in Science | Permalink

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Comments

Are you sure that switch was not NPR?

Posted by: Walter Wallis at Aug 18, 2004 4:28:48 PM

George,

These science tidbits are great. You wrote something months ago about flax oil I think, applied to bipolar depression (Churchill`s famously huge creative energies, and his `black dog` deep depressive phases). After a bunch of googling on that I found lots of articles and commercial products targeted to that, and to monopolar depression. It looks like the trials had it that cold pressed flax helped in quantities ranging from 2tbsp to 6tbps per day for monopolar depression, with more than that slipping monopolar over to manic. Trials with cold pressed cold-ocean-water fish oil(which contain high concentrations of two similar lipid molecules to that found in high concentration in flax), seemed to do a good job in bipolar and monopolar as well, in doses equivalent to =up to= 6 1000mg fish oil gels per day. More than that decreases the effect to the point of disappearance. In a sample of one, peformed on a male anglosaxon subject living in Chamonix France, the high flax dose did indeed produce hyperactivity. As far as I can tell the fish oil did wonders for my hangover recovery performance.

I bring all this up, because it seems to me anxiety and sleep problems are part of the big constellation of symptoms psychiatry has statistically correlated with `depression` measures. (Dont have a DSM handy to cite chapter and verse.) Vaguely it seems to me anxiety or sleeplessness have some kind of `mania` flavor in there. So what the heck; at the risk of damping a bit you spurts of fiskitude(not mentioned in the DSM...yet), would there be anything wrong with trying the fish oil thing, experimentally as it were? In any case I got interested in the whole essential lipids point of view from one of YOUR blog entries.

BTW, as it regards the larger subject of neurodegenerative diseases, the lipids hypothesis out there on the web make sense some how. The cell membranes of neurons contain a lot of omega-3 lipids apparently, to the point of making up a double digit pourcentage of the dry weight of the brain. Apparently there are a lot in every cell membrane, along with other lipids and lipid-protein or lipid-X type of combinations that have been absorbed in food and/or remanufactured. The thing is, since industrialisation of our food intake became generalised in the last handful of decades, we are absorbing lipids that do not exist in nature, and of those that do, we are absorbing wildly different ratios of one lipid type to the others. So on the one hand we have engineered lipid molecules getting incorporated in our cell membranes that do not have the same properties as the lipids that the cells ancient biochemical processes recognize them as. Not good. And on the other hand, the ratios of one lipid type versus another in our food wanker up the biochemical processing plants by saturating certain reaction paths with one type of oil versus another.

In particular, there is apparently a biochemical path in our cells that can convert the type of essential lipid found in high concentrations in flax seed into the two essential lipids found in ocean fish oil(and algae, and kelp), the latter two being critical components of neurons membranes.. Without that path, landlocked humans could never have lived for long without eating ocean fish.

Thing is, that path apparently contains transformation steps that are also used in the transformation of the type of lipids found in huge quantity in vegetable oils. At pre-industrial ratios of intake between the essential lipids and others, the essential lipids got a good share of the limited transformation capacity vs the others. However now, landlocked humans that do not much ocean fish and consume the average american diet end up starving later steps that transform the flax type of oil into the fish kinds. So, lots of depression and neurodegerative diseases (...and cardiovascular disease) among modern populations that eat the average grocery store diet but do not eat much cold water fish.

The latest thing that piqued my interest in this point of view was a fairly simple idea of how we got screwed up in our lipid intakes. The idea semms to be that industrially produced, long shelf life packaged, foods can be pretty cheaply engineered so as to stabilise for very long periods every type of nutrient and organic molecule that is currently recognized as `essential`(vitamins etc that the body cannot manufacture) =except for= two or three lipid molecules. They are easily degraded by oxygen, light, and heat. So the lipids found in industrially produced foods tend to be engineered ones, notably; refined oils that have lost their original geometry as produced by the plant that made them through heating and so on, and hydrogenated oils(made by bubbling hydrogen through vegetable oils).

Anyhoo(IMAO rocks) your mention of the anxiety and sleeplessness thing with respect to neurological research kind of set off this longish tangential stab at an interesting post.

Cheers

Posted by: Bryan Travis at Aug 23, 2004 8:56:48 PM

Uh. Wow.
I have a better and simpler thought: How about the theraputic benefits of Maker's Mark (a little water and no ice), and staying away from deep navel-gazing? Birkenstocks, especially when worn with dark socks, and ANY scented oil are signs of harmful mental imbalance.
Ya'll are too smart to fall into the trap of thinking too much, aren't you?
Great site, very interesting comments, and an entertaining mix of subjects. Thank you and keep up the good work.

Dan Patterson
Winston-Salem, NC

Posted by: Dan Patterson at Aug 26, 2004 12:45:12 PM

Maker`s Mark. Hmmm. I am kind of a cheap bastard and so drink mainly cheap red wine out of those monster 10 liter mylar bag boxes. The importantt thing being the molecules you are getting right? Now in red wine you got the alcohol, the sugars, the tannins, the polyphenols, and that reservatrol molecule. The alcohol activates dopamine(for pleasure) and inhibits...inhibitions(yeah, that`s the ticket). The reservatrol has powerful cardio vascular benefits(the so called french paradox..). The polyphenols ummm, are like antioxidative, and help fight gum disease too. Sugars taste good and provide a bit of quick energy. Tannins are similar that bitter crap they put in whiskey to make them taste like shit. The benefit though is that if you absorb those together with cheese at the end of your meal some enzymes or whatever turn some of the combination into....soap which helps wash out your guts. Tyler Durden says soap is the cornerstone of civilisation, and he (fictionally, OK) made lots of soap(and nytro, and blasting caps, and dynamite). So who am I to argue with Tyler Durden?

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